
The Margaret Grigg Nanjing Friendship Garden commemorates longstanding scientific and cultural exchanges between the Missouri Botanical Garden and Chinese botanical institutions, culminating in the monumental Flora of China project. The Chinese garden also honors the sister city relationship between St. Louis and Nanjing, established in 1979 as the first such relationship between the United States and China. Construction of the Chinese garden was made possible by a gift from Margaret Grigg Oberheide in memory of her parents, Estelle and Robert Blanke.

Major features of the garden were gifts from the city of Nanjing. In return, the Garden and the city of St. Louis gave a children's playground to Nanjing. The award-winning Chinese American architect Yong Pan, in consultation with Environmental Planning and Design of Pittsburgh, Pennsylvania, designed the Margaret Grigg Nanjing Friendship Garden.
The Margaret Grigg Nanjing Friendship Garden is the most authentic Chinese garden of its size in the United States.